JM pharma webinars

Access our free webinars below, offering valuable insight for research chemists and process development in the pharmaceutical, fine chemical, agrochemical, speciality and F & F industries.

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Homogeneous ester hydrogenation has evolved into an efficient and cost-effective transformation and provides greener access to primary alcohols, important targets in pharmaceutical and flavour & fragrances chemistry. This webinar provides a deeper understanding of the application of the technology. This webinar is presented by Dr Antonio Zanotti-Gerosa from Johnson Matthey.

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Catalysis has been, for a long time, an established tool in the fine chemicals industry. Yet, application scope, catalysts performance, process understanding as well as our expectations are continually evolving. It is worth examining once again the answers to some basic questions: Why catalysis? Why new catalysts? Which new catalysts? Here, we briefly overviewed the rationale for sustainability, economics, technical complementarity of the homogeneous, heterogeneous and biocatalytic technologies offered by Johnson Matthey.

This webinar was presented by Dr Antonio Zanotti-Gerosa and Dr Danny Mortimer from Johnson Matthey.

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Choosing the ideal solid form is a crucial point in the life cycle of a molecule. Therefore, it is always best to conduct a thorough search to identify as many forms (polymorphs, salts and cocrystals) as possible to allow you to select the one with the preferred physical/chemical properties and for IP. However, limited material can make this challenging. A well-designed screen, including multiple crystallisation techniques with a diverse set of solvents, can be carried out with little material prioritising analytical techniques to identify solid forms of interest. Furthermore, as a solid form progresses through development, unexpected issues can arise. New forms, oiling out, change in impurity profiles caused by changes in scale, can result in the scrapping of batches, extra production steps or the reset of a molecule potentially costing millions. To minimise risk, crystallisation development driven by Quality by Design (QBD) should be undertaken as soon as possible. Using PAT tools, modelling, design of experiment studies coupled with expert understanding of the solid form and solubility landscape, a scalable, robust process that will give the desired outcome can be built and developed at an early stage of development.

This webinar was presented by Dr Thomas Kendall from Johnson Matthey.

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