Analytical method development

Our experts can develop, optimise and validate analytical methods on a wide range of instrumentation and detectors. We deliver methods for complex compounds throughout early research to GMP standards in line with ICH and FDA/MHRA requirements.

  • Method development, qualification, validation and transfer
  • ICH stability including photostability
  • Impurity isolation and identification
  • Characterisation of APIs and precursors
  • Reference material program

We use state-of-the-art instrumentation:

UPLC with TUV, PDA, and QDadetectors

HPLC with VWD, PDA, CAD, MALS, RI, FD, and MS detectors
GC (direct and headspace injection) with FI, EC, and MS detectors
IC with conductivity and UV detectors
Spectroscopy (IR, NMR, ICP-OES, ICP-MS, UV/Vis, Polarimeter)
Physical Characterization (XRPD and Particle Size Analyzer)
Thermal Analysis (TGA & DSC) and Wet Chemistry (TOC, Titrators, RI)
    Physical and chemical analysis Crystallography
    The Single Crystal X-Ray Diffraction (SCXRD) laboratory at Johnson Matthey
    black crystals

    Read Chemistry World article

    Exploring the advantages of single-crystal x-ray diffraction in pharma

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    Physicochemical characterisation services

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    Liz Edmond

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