Crystallisation development

Developing a robust crystallisation process to isolate the optimal solid form of an API is an essential step in API development. Identifying the crystallisation approach, solvent system(s), controlling form, crystal habit and delivering a consistent uniform PSD from a single process step can be very challenging.

Applying expertise in, solid state, PAT and computational modelling all underpin our development of crystallisation processes, allowing us to deliver the best outcome at the required scale. We also work on remediating existing crystallisations, which can have a variety of issues such as oiling out, isolating the wrong polymorphic form or just long filtration times.

  • Maximise process yields
  • Control form, morphology and particle size distribution
  • Create processes suitable for scale-up
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pyrimethanil tartrate structure

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Liz Edmond

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