Nitroreductase kit

Johnson Matthey’s kit contains 8 nitroreductase (NTR) enzymes for the reduction of nitroaromatic compounds to their corresponding anilines. The enzymes have been selected for their great activity on a wide selection of substrates and to accommodate the different synthetic needs of our customers. Substrates accepted by the NTR enzymes include aromatic and heteroaromatic nitro compounds(1).  

An outstanding feature of this catalytic system is the exquisite chemoselectivity. Substrates containing halogens or other functional group that could be lost or reduced upon chemical nitroreduction (i.e. O-benzyl, C-C double bonds, nitriles) are reduced by the nitroreductase vanadium catalytic system only at the nitro-moiety, leaving untouched the other functional groups.