Protodehalogenation catalysts

Halogenated compounds are among the most common and important building blocks in starting materials and reaction intermediates utilised in the synthesis of molecules across the pharmaceutical, agrochemical, and fine chemical sectors. Protodehalogenation is widely used across these industries to selectively replace halogen groups with hydrogen. The transformation is often employed following halogen-based functionalisation reactions, where the halogen group has facilitated earlier steps. Aryl and heteroaryl halide removal is an example of industrially relevant proto dehalogenation. 

Achieving selective protodehalogenation in complex molecules with multiple reducible functionalities can be challenging. It requires careful catalyst selection and optimisation of reaction conditions to achieve the desired transformation efficiently, while preserving other functional groups.