Ruthenium Noyori catalysts

Johnson Matthey’s portfolio of ruthenium Noyori catalysts are widely applied in industry for the enantioselective reduction of ketones and imines under transfer hydrogenation conditions. The rutheniun Noyori catalyst portfolio is complemented by our iridium Noyori catalysts, covering a range of steric and electronic features. Very high enantioselectivity (>95%) is obtained at low catalyst loadings on benzylic ketones (cyclic and acyclic), ortho substituted benzophenones, alpha-halo ketones, and cyclic imines. Aliphatic imines, meta- and para-substituted benzophenones and direct reductive amination may require specific catalysts and optimisation of conditions.