Buchwald-Hartwig amination catalysts

Carbon-nitrogen bonds are found ubiquitously in modern small molecules for the applications of pharmaceuticals, agrochemicals, flavors / fragrances, and performance materials. The advent of general methodologies for transition metal catalyzed C-N bond formation, popularly known as the Buchwald-Hartwig amination (BHA), has significantly accelerated the discovery and commercial manufacturing of innovative small molecules. Both ligand and precatalyst design are crucial elements in the development of effective Buchwald-Hartwig amination catalysts.  

Johnson Matthey offers an extensive portfolio of phosphine ligated Pd precatalysts designed for a range of Buchwald-Hartwig aminations from straightforward to highly challenging coupling reactions.