Ruthenium Baratta catalysts
Walter Baratta of University of Udine (Italy), developed a class of achiral ruthenium catalysts that combine diphosphine ligands and aminomethylpyridine (AMPY). These catalysts display outstanding activity under both transfer hydrogenation and pressure hydrogenation conditions, which is commonly achieved with low catalyst loadings. Ruthenium Baratta catalysts are very effective in the chemo- and diastereoselective reduction of carbonyls (ketones and aldehydes) and to some extent esters. Basic conditions are required, but the high activity and the scope for reaction optimisation also makes these catalysts suitable for base-sensitive substrates.
Advantages of Ru Baratta catalysts:
- Very high activity in C=O reduction.
- Active in both transfer hydrogenation and hydrogenation conditions.
- Basic conditions required, but optimisable even for base-sensitive substrates.
[dppf RuCl₂ AMPY]
Product number: C1-720
CAS number: 1287255-62-2
Mol weight: 834.49
Reaction type: hydrogenation, ester hydrogenation
[dppb RuCl₂ AMPY]
Product number: Ru-721
CAS number: 850424-32-7
Mol weight: 706.59
Reaction type: hydrogenation, ester hydrogenation
