Hydrogenolysis catalyst technologies
Hydrogenolysis reactions are very common in the production of molecules for the pharmaceutical and fine chemical sectors, as they provide a relaible way to remove protecting groups or modify functional groups without affecting the rest of the molecule. Most commonly, carbon-heteroatom single bonds are cleaved with hydrogen added to both fragments to form stable products. Solvent choice is often critical and can be used to fine-tune reaction rates and selectivity.
A range of palladium catalytic hydrogenolysis transformations can be carried out, including deprotections, hydrodehalogenations, and the Rosenmund reaction. The Rosenmund reaction is the hydrogenolysis of acyl chlorides to the corresponding aldehyde and is a standard method for the conversion of carboxylic acids to aldehydes.
Johnson Matthey offers an extensive portfolio of catalysts designed for catalytic hydrogenolysis.
Hydrogenolysis catalyst options
5% Pd / carbon
Product number: Cataflo Pd1
Metal state: reduced
Catalyst form: dry
Particle size: 500 um
5% Pd / carbon
Product number: Cataflo Pd2
Metal state: reduced
Catalyst form: dry
Particle size: 500 um
5% Pd / carbon
Product number: Cataflo Pd3
Metal state: reduced
Catalyst form: dry
Particle size: 200 um
3% Pd / Al₂O₃
Product number: Cataflo Pd4
Metal state: reduced
Catalyst form: dry
Particle size: 0.8 mm
3% Pd / Al₂O₃
Product number: Cataflo Pd5
Metal state: reduced
Catalyst form: dry
Particle size: 0.8 mm
3% Pd / Al₂O₃
Product number: Cataflo Pd6
Metal state: reduced
Catalyst form: dry
Particle size: 250 um
