Academic Publications

The impact of platinum group metal catalysts in fine chemical synthesis 
Chimicao Oggi/Chemistry Today. 2025 31(3), 32-35
Keywords: heterogeneous catalysts, PGM recycling, life cycle analysis

Productive homogeneous hydrogenation of fatty esters with carbosylate SNS ruthenium catalysts 
Chem. Eur. J. 2025 31(44), e202501898
Keywords: homogeneous catalysts, ester hydrogenation, Gusev^TM catalysts, C1-751

Catalyst activation and speciation involving DyadPalladate precatalysts in Suzuki-Miyaura and Buchwald-Hartwig cross-couplings
Organometallics 2025, 44(5), 654-664
Keywords: homogeneous catalysts, DyadPalladates^TM,  catalyst activation and speciation, oxidative addition, Suzuki–Miyaura cross-coupling, Buchwald–Hartwig amination

Direct synthesis of polyesterether from ethylene glycol
ACS Sustainable Chem. Eng. 2025, 13(15), 5703-5711*
Keywords: homogeneous catalysts, dehydrogenation, hydrogen borrowing, C1-720

Redox-powered autonomous directional C-C bond rotation under enzyme control
Nature 2025, 644, 96-101*
Keywords: biocatalysis, alcohol dehydrogenase

*Customer research using JM catalysts

Design to refine for homogeneous catalysts
Chimica Oggi/Chemistry Today 2024, 42 (6), 16-18
Keywords: homogeneous catalysts, metal scavengers, PGM recycling 

Riboflavin with H₂-driven or electrochemical recycling: a cheap cofactor system for supporting biocatalytic alkene reduction
ChemCatChem 2024, 17(5), e202401578*
Keywords: biocatalysis, ENE reductase

Biosynthesis parameters control the physicochemical and catalytic properties of microbially supported Pd nanoparticles
Small 2024, 20(31), 2311016*
Keywords: biocatalysis

Peroxygenase-catalyzed allylic oxidation unlocks telescoped synthesis of (1S,3R)-3-hydroxycyclohexanecarbonitrile
ACS Catal. 2024, 14(5), 2985-2991*
Keywords: biocatalysis, alcohol dehydrogenase, ENE reductase, glucose dehydrogenase

Asymmetric monoreduction of  α,β-dicarbonyls to α-hydroxy carbonyls by ENE reductases
ACS Catal. 2024, 14(20), 15713-15720*
Keywords: biocatalysis, ENE reductase 

Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(sp3)-S stereocentres
Nature Communications 2024, 15, 8332
Keywords: biocatalysis, alcohol dehydrogenase, ENE reductase

Accessing active fragments for drug discovery utilising nitroreductase biocatalysis
ChemCatChem 2024, 25(18), e202400428*
Keywords: biocatalysis, nitroreductase

Broadening the substrate scope of aldolases through metagenomic enzyme discovery
ChemBioChem 2024, 25(20), e202400278
Keywords: biocatalysis, aldolases

G-EnzyBeads for biocatalysis screening faciliated by volumetric dosing
Org. Process Res. Dev. 2024, 28(8), 3404-3413*
Keywords: biocatalysis, IRED-18

Development of a cost-efficient process toward a key synthetic intermediate of teh EZH2 inhibitor PF-06821497
Org. Process Res. Dev. 2024, 28(6), 2260-2268*
Keywords: biocatalysis, ADH-101

*Customer research using JM catalysts

Catalytic, Z-selective, semi-hydrogenation of alkynes with a zinc-anilide complex
J. Am. Chem. Soc. 2023, 145 (13), 7667-7674
Keywords: homogeneous catalysts, alkynes semi-hydrogenation

Realizing the continuous chemoenzymatic synthesis of anilines using an immobilized nitroreductase
ACS Sustainable Chemistry & Engineering. 2023, 11 (23), 8556-8561
Keywords: biocatalysis, nitroreductase

Amine synthesis using the amine donor N-phenyl putrescine and the Johnson Matthey transaminase biocatalyst library
Johnson Matthey Technology Review 2023, 67(4), 428-435
Keywords: biocatalysis, transaminase

Realizing the continuous chemoenzymatic synthesis of anilines using the immobuluzed nitroreductase
ACS Sustainable Chem. Eng. 2023, 11(23), 8556-8561
Keywords: biocatalysis, nitroreductase

From milligram to kilogram manufacture of AZD4573: making it possible by application of enzyme-, iridium-, and palladium-catalyzed key transformations
Org. Process Res. Dev. 2022, 26 (3), 601-615*
Keywords: homogeneous catalysts

Synergistic nitroreductase/vanadium catalysis enables chemoselective nitro reductions to anilines in the abscence of hydrogen gas
Current Research in Chemical Biology 2022, 2, 100026
Keywords: biocatalysis, nitroreductase

*Customer research using JM catalysts

Understanding the activation of air-stable Ir(COD)(Phen)Cl precatalyst for C-H borylation of aromatics and heteroaromatics
Org. Lett. 2021, 23 (5), 1561-1565
Keywords: homogeneous catalysts, borylation, C-H activation

Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution
Tetrahedron Letters. 2021, 66, 152764
Keywords: homogeneous catalysts, C=O asymmetric hydrogenation, Noyori catalysts

Enantioselective synthesis of Ozanimod, the active pharmaceutical ingredient of a new drug for multiple sclerosis
Eur. J. Org. Chem. 2021, 12, 1924-1930
Keywords: homogeneous catalysts, C=N asymmetric transfer hydrogenation, reductive animation, C1-318, C1-314

Asymmetric hydrogenation in industry
Advances in Catalysis. 2021, 68, 241-283
Keywords: homogeneous catalysts, asymmetric hydrogenation

Prepration of neutral trans-cis [Ru(O₂CR)₂P₂(NN)], cationic [Ru(O₂CR)₂P₂(NN)](O₂CR) and pincer [Ru(O₂CR)₂P₂(NN)](P=PPh₃,P₂=disphosphine) carboxylate complexes and their application in the catalytic carbonyl compounds reaction
Organometallics, 2021, 40 (8), 1086-1103
Keywords: homogeneous catalysts, C=O hydrogenation

Process development and protein engingeering enhanced nitroreductase-catalyzed reduction of 2-methyl-5-nitro-pyridine
Org. Process Res. Dev. 2021, 25(3), 648-653
Keyword: biocatalysis, nitroreductase

Enantio-complementary continuous-flow synthesis of 2-aminobutane using covalently immobilized transmianses
ACS Sustainable Chem. Eng. 2021, 9(11), 4122-4129
Keywords: biocatalysis, transaminase

A comparison of different approaches to the conversion of carbon dioxide into useful products: part I
Johnson Matthey Technology Review 2021, 65(2), 180-196
Keyword: biocatalysis

Reconciling the sustainable manufacturing of commodity chemicals with feasible technoeconomic outcomes: assessing the investment case for heat integated aerobic gas fermentation
Johnson Matthey Technology Review 2021, 65(3), 375-394
Keywords: biocatalysis

Growth amplification in ultrahigh-throughput microdroplet screening increases sensitivity of clonal enzyme assays and minimizes phenotypic variation
Lab on a Chip 2021, 21, 163-173*
Keywords: biocatalysis

*Customer research using JM catalysts

Application of transition-metal catalysis, biocatalysis, and flow chemistry as state-of-the-art technologies in the synthesis of LCZ696
J. Org. Chem. 2020, 85(11), 6844-6853*
Keywords: homogeneous catalysts, biocatalysis, C=O asymmetric hydrogenation

Efficient and selective solvent-free homogeneous hydrogenation of aldehydes under mild conditions using [RuCl₂(dppb)(ampy)]
Tetrahedron Letters 2020, 61(13), 151677
Keywords: homogeneous catalysts, hydrogenation, Ru-721

Biocatalytic reduction of activated cinnamic acid derivatives
Johnson Matthey Technology Review 2020, 64 (4), 529-536
Keywords: biocatalysis, ENE reductases

Chemo-enzymatic cascades
Applied Biocatalysis: The Chemist's Enzyme Toolbox, Whittall, J. and, P. W. (Eds.), John Wiley & Sons, 2020; ch. 12
Keywords: biocatalysis, nitroreductase

Biocatalytic reduction of activated cinnamic acid derivatives
Johnson Matthey Technology Review 2020, 64(4), 529-536
Keywords: biocatalysis, ENE reductase

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships
Science Advances 2020, 6(21)
Keywords: biocatalysis, imine reductase

Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
Nature Communication 2020, 11, 1454*
Keywords: biocatalysis, alcohol dehydrogenase

*Customer research using JM catalysts

Technical considerations for scale-up of imine-reductase-catalyzed reductive amination: a case study
Org. Processs Res. Dev. 2019, 23(6), 1262-1268
Keywords: biocatalysis, imine reductases

Structural diversity in ruthenium-catalyzed asymmetric transfer hydrogenation reactions
Topics in Organometallic Chemistry 2019, 65, 73-114
Keywords: homogeneous catalysts, asymmetric transfer hydrogenation

The coming of age of homogeneous ester hydrogenation - Gusev catalysts: why, how, and when to use them
Chimica Oggi/Chemistry Today 2019, 37(4)
Keywords: homogeneous catalysts, ester hydrogenation, Gusev^TM catalysts, C1-750 

Process economics and atom economy for industrial cross coupling applications via L_nPd(0) - based catalysts
Topics in Organometallic Chemistry 2019, 65, 161-198
Keywords: homogeneous catalysts 

One-pot biocatalytic cascade reduction of cyclic enimines for the preparation of diastereomerically enriched N-heterocycles
J. Am. Chem. Soc. 2019, 141(49), 19208–19213*
Keywords: biocatalysis, ENE reductase

Catalyst-directed chemoselective double amination of bromo-chloro(hetero)arenes: a synthetic route toward advanced amino-aniline intermediates
Org. Lett. 2018, 20(8), 2301-2305
Keywords: homogeneous catalysts

Development of concise two-step catalytic approach towards lasofoxifene precurosr nafoxidine
Bioorganic & Medicinal Chemistry 2018, 26, 2691-2697
Keywords: homogeneous catalysts, alfa-arylation

Chemoenzymatic synthesis of substituted azepanes by sequential biocatalytic reduction and organolithium-mediated rearrangement
J. Am. Chem. Soc. 2018, 140(51), 17872–17877*
Keywords: biocatalysis, imine reductase

*Customer research using JM catalysts

Acid promoted Ir-Pⁿ complex catalyzed hydrogenation of heavily hindered 3,4-diphenyl-1,2-dihydronaphthalenes: asymmetric synthesis of lasofoxifene tartrate
Org. Chem. Front. 2017, 4, 2311-2322
Keywords: homogeneous catalysts, asymmetric hydrogenation

Mild N-alkylation of amines with alcohols catalyzed by the acetate Ru(OAc)₂(CO)(DiPPF) Complex
Chem. Eur. J. 2017, 23(58), 14416-14419
Keywords: homogeneous catalysts, hydrogen borrowing

Hydrogenation and reductive amination of aldehydes using triphos ruthenium catalysts
ChemCatChem 2017, 10(5), 1012-1018
Keywords: homogeneous catalysts, ester hydrogenation

A chemoenzymatic route to chiral intermediates used in the multikilogram synthesis of a gamma secretase inhibitor
Org. Process Res. Dev. 2017, 21(6), 871–877*
Keywords: biocatalysis, alcohol dehydrogenase 

Direct alkylation of amines with primary and secondary alcohols through biocatalytic hydrogen borrowing
Angewandte Chemie International Edition 2017, 56(35), 10491-10494
Keywords: biocatalysis, imine reductase

Understanding and overcoming the limitations of Bacillus badius and Caldalkalibacillus thermarum amine dehydrogenases for biocatalytic reductive animation
ACS Catal. 2017, 7(5), 3204–3209
Keywords: biocatalysis, amine dehydrogenase

Johnson Matthey: a technology provider perspective to biocatalysis in the fine chemicals industry
Biocatalysis, 2017, 168-189
Keywords: biocatalysis

*Customer research using JM catalysts

Biocatalytic dynamic kinetic resolution for the synthesis of atropisomeric biaryl N-oxide Lewis base catalysts
Angewandte Chemie Int. Ed. 2016, 55(36), 10755-10759
Keywords: biocatalysis

Development of the asymmetric hydrogenation step for multikilogram production of etamicastat
Org. Process Res. Dev. 2016, 20(4), 724-732*
Keywords: homogeneous catalysts

The development of phosphine-free "tethered" ruthenium (II) catalysts for the asymmetric reduction of ketones and imines
The Chemical Record 2016, 16(6), 2623-2643
Keywords: homogeneous catalysts, asymmetric transfer hydrogenation, C1-300, C1-310, C1-314 

Convergent synthesis of the renin inhibitor aliskiren based on C5-C6 disconnection and CO₂H-NH₂ equivalence
Org. Process. Res. Dev. 2016, 20(2), 270-283
Keywords: homogeneous catalysts, asymmetric hydrogenation

Transfer hydrogenation and hydrogenation of commercial-grade aldehydes to primary alcohols catalyzed by 2-(aminomethyl)pyridine and pincer benzo[h]quinoline ruthenium complexes
ChemCatChem 2016, 8(13), 2279-2288
Keywords: homogeneous catalysts, hydrogenation, Ru-721, C1-720

Reduction of activated carbon-carbon double bonds using highly active and enantioselective double bond reductases
Johnson Matthey Technology Review 2016, 60(4), 243-249
Keywords: biocatalysis, ENE reductase

*Customer research using JM catalysts

A convenient palladium-catalyzed azaindole synthesis
Synlett 2015, 26(02), 197-200
Keywords: homogeneous catalysts

An efficient catalytic asymmetric synthesis of a β²-amino acid on a multikilogram scale
Org. Process Res. Dev. 2014, 18(1), 135-141
Keywords: homogeneous catalysts, asymmetric hydrogenation, Ru-138, Ru-137

Study of chemoselective asymmetric hydrogenation of (1-bromo-1-alkenyl)boronic esters with iridium P^N complexes
Tetrahedron 2014, 70(16), 2654-2660*
Keywords: homogeneous catalysts, asymmectric hydrogenation

Synthesis and catalytic applications of an extended range of tethered ruthenium(II)/η⁶-arene/diamine complexes
Organometallics 2014, 33(19), 5517-5524
Keywords: homogeneous catalysts, asymmetric transfer hydrogenation

Enzymatic desymmetrising redox reactions for the asymmetric synthesis of biaryl atropisomers
Chemistry - A European Journal 2014, 20(41), 13084-13088
Keywords: biocatalysis, desymmetrization

*Customer research using JM catalysts

Development of a stepwise reductive deoxygenation process by Ru-catalysed homogeneous ketone reduction and Pd-catalysed hydrogenolysis in the presence of Cu salts
ChemCatChem 2013, 5(5), 1205-1210
Keywords: homogeneous catalysts, heterogeneous catalysts, Pd/C 

Application of [BoPhozRh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene
Tetrahedron Letters 2012, 53(9), 1025-1028
Keywords: homogeneous catalysts, C=C asymmetric hydrogenation

Development of Pd/C-catalyzed cynanation of aryl halides
J. Org. Chem. 2011, 76(2), 665-668*
Keywords: heterogeneous catalysts, cyanation, Pd/C

*Customer research using JM catalysts

A feasibility study on the synthesis of phenylephrine via ruthenium-catalyzed homogeneous asymmetric hydrogenation
Tetrahedron: Asymmetry 2010, 21(20), 2479-2486
Keywords: homogeneous catalysts, C=O asymmetric hydrogenation, Noyori catalysts 

Homogeneous asymmetric hydrogenation: recent trends and industrial applications
Current Opitions Drug Discovery & Development 2010, 13(6), 698-716
Keywords: homogeneous catalysts, C=O asymmetric hydrogenation, Noyori catalysts 

Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing α_Vβ₃/α_Vβ₅ integrin antagonist enantioselective synthesis and stereochemical studies
J. Org, Chem. 2008, 73(6), 2302-2310
Keywords: homogeneous catalysts, C=C asymmetric hydrogenation

Rh(III) and Ir(III)-catalyzed asymmetric transfer hydrogenation of ketones in water
Chemistry - A European Journal 2008, 14, 2209
Keywords: homogeneous catalysts, C=O transfer hydrogenation, Ir-115, Rh-120 

Computational study of the factors controlling enantioselectivity in ruthenium(II) hydrogenation catalysts
Inorg. Chem. 2008, 47(7), 2674-2687
Keywords: homogeneous catalysts, C=O transfer hydrogenation, Noyori catalysts

On water and in air: fast and highly chemoselective transfer hydrogenation of aldehydes with iridium catalysts 
Chemistry - A European Journal 2006, 45(40), 6718-6722
Keywords: homogeneous catalysts, C=O transfer hydrogenation, Ir-115, Rh-120