Glucose dehydrogenase enzyme technology 

Glucose dehydrogenase (GDH enzymes) catalyses the oxidation of D-glucose to D-glucolactone, while reducing in turn NAD+ or NADP+ to NADH and NADPH. The product of this reaction, D-glucolactone, spontaneously and irreversibly hydrolyses in water to gluconic acid, which favors the formation of reduced NADH and NADPH.
 

Advantages of using glucose dehydrogenase:

  • GDH enzyme is an efficient system for cofactor regeneration owing to its cheap substrate, the favourable reaction equilibrium towards the reduced cofactor and the high activity of the enzyme.
  • Easily scalable technology due to the GDH enzyme stability in a wide range of reaction conditions.

GDH enzyme options

Glucose dehydrogenase enzyme - Johnson Matthey
GDH-5
Enzyme class number: 1.1
Optimal pH: 6.5-9.0
Reaction type: cofactor recycling
GDH Enzyme - Johnson Matthey
GDH-8
Enzyme class number: 1.1
Optimal pH: 9.0-12.0
Reaction type: cofactor recycling
GDH-101
Enzyme class number: 1.1
Optimal pH: 6.0-9.0
Reaction type: cofactor recycling

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