Imine reductases – IREDs (RedAms) | Johnson Matthey

IREDs enzyme technology

Johnson Matthey’s imine reductases (IREDs) biocatalysts are used to produce enantiopure primary, secondary and tertiary amines. These IREDs can reduce preformed imines as well as intermolecular reductive amination (also known as RedAms). All Johnson Matthey’s IREDs catalyse reductive amination of ketones with small aliphatic amines. A selection of the IRED enzymes are capable of accepting bulky aniline derivatives as the amine donor molecule in intermolecular reductive amination. IREDs can be engineered to achieve the optimal activity and selectivity of your application.

Advantages of using IREDs (or RedAms):

Exhibit high high chemo-, regio- and enantioselectivity, producing chiral amines with high enantiomeric excess in aqueous media, and under mild conditions of temperature and pressure.
Works efficiently in combination with a cofactor recycling system for the regeneration of NAD(P)+ cofactor.
IRED enzymes present a wide substrate scope and good operational stability, making them highly versatile for the synthesis of diverse amines (1,2).