Alcohol dehydrogenase enzyme technology

Alcohol dehydrogenase enzyme (also known as keto reductase) catalyses the reduction of ketones and aldehydes to the corresponding alcohols. Enantiopure alcohols can be obtained using Johnson Matthey’s ADH enzyme portfolio. Alcohol dehydrogenase enzymes can be engineered to achieve the optimal activity and selectivity of your application.
 

Advantages of using an ADH enzyme:

  • Exhibit high chemo-, regio- and enantioselectivity, producing chiral alcohols with high enantiomeric excess in aqueous media, under mild conditions of temperature and pressure.
  • Catalyse the reduction of a wide variety of carbonyl compounds (ketones and aldehydes) to their corresponding alcohols, making them versatile tools in synthetic chemistry.
  • ADH enzyme technology is easily scalable for industrial application, making them practical for manufacturing large quantities of chiral alcohols.

ADH enzyme options

ADH-101
Enzyme class number: EC 1.1
Optimal pH: 6.5-7.5
Reaction type: C=O reduction
ADH-104
Enzyme class number: EC 1.1
Optimal pH: 6.0-6.5
Reaction type: C=O reduction
 
ADH-105
Enzyme class number: EC 1.1
Optimal pH: 6.0-7.0
Reaction type: C=O reduction
ADH-110
Enzyme class number: EC 1.1
Optimal pH: 6.5-7.5
Reaction type: C=O reduction
ADH-150
Enzyme class number: EC 1.1
Optimal pH: 6.5-7.5
Reaction type: C=O reduction
ADH-153
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.5
Reaction type: C=O reduction
 
ADH-159
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.5
Reaction type: C=O reduction
ADH-160
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.5
Reaction type: C=O reduction
ADH-171
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
ADH-19
Enzyme class number: EC 1.1
Optimal pH: 6.0-7.5
Reaction type: C=O reduction
 
ADH-20
Enzyme class number: EC 1.1
Optimal pH: 6.0-6.5
Reaction type: C=O reduction
ADH-220
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
ADH-230
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
ADH-244
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
 
ADH-27
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
ADH-61
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction
ADH-62
Enzyme class number: EC 1.1
Optimal pH: 6.0-9.0
Reaction type: C=O reduction

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