Miyaura borylation and Hartwig borylation catalysts

Organoboron reagents are valuable materials due to the widespread application of the Suzuki-Miyaura coupling in the manufacturing of industrially important small molecules. Traditionally, organoboron substrates are prepared using highly reactive organometallic reagents. These conditions often require cryogenic conditions and suffer from poor functional group compatibility. Catalytic borylation reactions are attractive alternatives since they operate under mild conditions and can be employed across a wide range of substrates.  

The Pd-catalysed Miyaura borylation reaction has been widely utilised across the chemical industry and can often be telescoped with the subsequent Suzuki-Miyaura coupling. Methodologies for the Hartwig iridium catalyzed borylation of C-H bonds are also well developed. Iridium catalyzed borylation reactions operate under even milder conditions than the Miyaura borylation and do not require pre-functionalized substrates. Also, in many cases regioselectivity can be controlled by sterics rather than electronics. 

Johnson Matthey offers traditional Pd precatalysts as well as novel, air-stable, single component Ir precatalsyts for Hartwig and Miyaura borylation reactions.