Reductive amination catalysts
Reductive amination reactions are commonly used to create intermediates or complex molecular entities consisting of amine functional groups. Applications range from fine chemicals and pharmaceuticals to synthesise chiral intermediates and active pharmaceutical ingredients.
Reductive aminations are well-established chemical transformations that convert electrophilic carbonyl groups such as ketones and aldehydes into amines. Reactions proceed via a two-step mechanism via an imine formation followed reduction of the imine in the presence of a reducing agent such as hydrogen and a catalyst.
Heterogeneous catalysts
Use of heterogeneous palladium on carbon catalysts tend to favor the formation of secondary amines. Excess ammonia is often utilised to suppress hydrogenation of the carbonyl to the corresponding alcohol, to improve selectivity and limit unwanted side products.
5% Pd / carbon
Product number: 5R58
Metal state: reduced
Catalyst form: wet
Particle size: 30 um
5% Pd / carbon
Product number: 5R424
Metal state: unreduced
Catalyst form: wet
Particle size: 25 um
5% Pd / carbon
Product number: A503023-5
Metal state: reduced
Catalyst form: wet
Particle size: 25 um
5% Pd / carbon
Product number: A503032-5
Metal state: reduced
Catalyst form: wet
Particle size: 20 um
Biocatalysts
Our biocatalytic range als contains a variety of enzymes offering exquisite selectivity and sustainable one-pot reaction alternatives to suite your needs. The enzymes in our portfolio can reduce the preformed iminines as well as perform intermolecular reductive amination.
Imine reductases
