Carbonylation catalysts

Amides, esters, ketones, and other carbonly functional groups are ubiquitous across biologically active and industrially important small molecules. Carbonyls are also versatile functional handles that are often employed as key intermediates in the manufacturing of these important small molecules. The pre-existing carbonyl functionality derived from natural feedstocks is one of the challenges with traditional carbonyl group synthesis.

Palladium catalyzed carbonylation reactions are attractive methodologies for synthesising carbonyl derivatives because they are multi-component, atom economical, and utilize cheap and readily available carbon monoxide gas. Carbonylative cross couplings are also verstaile, often allowing derivatization of (hetero)aryl electrophiles to esters and amides by simply adding the desired amine or alcohol.

Johnson Matthey offers a selection of catalysts containing priveleged phosphine ligands for Pd catalyzed carbonylation reactions.