Transfer hydrogenation catalysts
Transfer hydrogenation is widely used in the synthesis of chiral alcohols and amines (including direct reductive amination). Heterogeneous and chiral catalysts can both be used for this transformation. Ruthenium, iridium, and rhodium chiral catalysts bearing sulphonylated diamine chiral ligands utilise formate salts or 2-propanol as reducing agents, which removes the need for pressure equipment. The technology is widely applied in industry due to its robustness, broad substrate tolerance, and compatibility with a wide range of reaction conditions along with a variety of organic solvents and aqueous systems.
Reactions with palladium heterogeneous catalysts are usually performed at solvent reflux under atmospheric nitrogen, but can be carried out at lower temperatures when needed. Solvent and hydrogen transfer agent choice are critical. The most commonly utilised solvents are methanol, ethanol, ethyl acetate, THF, and/or water. Hydrogen transfer agents are usually used in excess due to the possibility of decomposition, with the most commonly utilised being ammonium formate, sodium hypophosphite hydrate, and hydrazine hydrate.
Chiral transfer hydrogenation catalysts
Iridium Noyori catalysts
Ruthenium complexes
Ruthenium BINAP complexes
Ruthenium Noyori catalysts
Ruthenium Will catalysts
Heterogeneous transfer hydrogenation catalysts
5% Pd / carbon
Product number: 5R452
Metal state: unreduced
Catalys form: wet
Particle size: 25 um
5% Pd / carbon
Product number: 5R487
Metal state: reduced
Catalys form: wet
Particle size: 35 um
5% Pd / carbon
Product number: A102023-5
Metal state: reduced
Catalys form: wet
Particle size: 25 um
5% Pd / carbon
Product number: A503023-5
Metal state: reduced
Catalys form: wet
Particle size: 25 um
10% Pd / carbon
Product number: 10R487
Metal state: reduced
Catalys form: wet
Particle size: 35 um
