HTE catalyst screening plates

C-C and C-N couplings

Johnson Matthey’s 96-well catalyst screening plates are designed to accelerate hit identification for high-throughput experimentation workflows. The plates contain 24 unique precatalysts with 4 samples of each, designed for cross-coupling reactions. The homogeneous precatalysts included in each plate are selected from JM’s expansive product portfolio and loaded at a standard 1 μmol quantity using chemical-coated glass beads (ChemBeads)¹ solid dispensing technology.  

The selected catalysts provide you with a broad range of electronic and sterically diverse phosphine ligands. The high-throughput screening kit utilises JM’s proprietary π-allyl precatalyst scaffold for optimal catalyst activation and ensure accurate hit identification. 

 

High-throughput screening kit contents

Product number Description C-C plate C-N plate
Pd-62 PdCl2(MeCN)2 + +
Pd-93 Pd(dba)2 +
Pd-94 Pd2(dba)3 + +
Pd-100 PdCl2(PPh3)2 +
Pd-110 [Pd(allyl)Cl]2 + +
Pd-111 Pd(OAc)2 + +
Pd-117 PdCl2(DPEPhos) +
Pd-122 PdCl2[P(tBu)2(Ph)]2 +
Pd-123S PdCl2(S)-BINAP +
Pd-126 PdCl2(dppp) +
Pd-132 PdCl2(AmPhos)2 +
Pd-161 AmPhos Pd(crotyl)Cl + +
Pd-162 P(tBu)3 Pd(crotyl)Cl + +
Pd-166 PdCl2[P(tBu) (Cy)2]2 +
Pd-170 XPhos Pd(crotyl)Cl + +
Pd-171 RuPhos Pd(crotyl)Cl + +
Pd-172 SPhos Pd(crotyl)Cl + +
Pd-173 [BrettPhos Pd(allyl)]OTf + +
Product number Description C-C plate C-N plate
Pd-174 [tBuXPhos Pd(allyl)]OTf + +
Pd-175 [tBuBrettPhos Pd(allyl)]OTf +
Pd-177 XantPhos Pd(allyl)Cl + +
Pd-178 PCy3 Pd(crotyl)Cl +
Pd-181 P(o-tolyl)3 Pd(crotyl)Cl +
Pd-188 CyJohnPhos Pd(crotyl)Cl +
Pd-209 tBuXPhos Pd G6 +
Pd-210 tBuBrettPhos Pd G6 +
Pd-215 [RockPhos Pd(allyl)]OTf +
Pd-216 [Me3OMettBuXPhos Pd(allyl)]OTf +
Pd-217 CPhos Pd(crotyl) Cl +
Pd-218 [EPhos Pd(allyl)]OTf +
Pd-219 [GPhos Pd(allyl)]OTf +
Pd-220 [AlPhos Pd(allyl)OTf +
Pd-221 [MorDalPhos Pd(crotyl)OTf +
BPC-307 P(Ad)2(nBu) Pd G3 + +
Ni-132 Ni(PPh3)2(1-napthyl)Cl +

1. Tu, N.P.; Wang, T. RSC Med. Chem. 2026. DOI: 10.1039/D5MD00827A

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