HTE catalyst screening plates
C-C and C-N couplings
Johnson Matthey’s 96-well catalyst screening plates are designed to accelerate hit identification for high-throughput experimentation workflows. The plates contain 24 unique precatalysts with 4 samples of each, designed for cross-coupling reactions. The homogeneous precatalysts included in each plate are selected from JM’s expansive product portfolio and loaded at a standard 1 μmol quantity using chemical-coated glass beads (ChemBeads)¹ solid dispensing technology.
The selected catalysts provide you with a broad range of electronic and sterically diverse phosphine ligands. The high-throughput screening kit utilises JM’s proprietary π-allyl precatalyst scaffold for optimal catalyst activation and ensure accurate hit identification.
High-throughput screening kit contents
| Product number | Description | C-C plate | C-N plate |
|---|---|---|---|
| Pd-62 | PdCl2(MeCN)2 | + | + |
| Pd-93 | Pd(dba)2 | + | |
| Pd-94 | Pd2(dba)3 | + | + |
| Pd-100 | PdCl2(PPh3)2 | + | |
| Pd-110 | [Pd(allyl)Cl]2 | + | + |
| Pd-111 | Pd(OAc)2 | + | + |
| Pd-117 | PdCl2(DPEPhos) | + | |
| Pd-122 | PdCl2[P(tBu)2(Ph)]2 | + | |
| Pd-123S | PdCl2(S)-BINAP | + | |
| Pd-126 | PdCl2(dppp) | + | |
| Pd-132 | PdCl2(AmPhos)2 | + | |
| Pd-161 | AmPhos Pd(crotyl)Cl | + | + |
| Pd-162 | P(tBu)3 Pd(crotyl)Cl | + | + |
| Pd-166 | PdCl2[P(tBu) (Cy)2]2 | + | |
| Pd-170 | XPhos Pd(crotyl)Cl | + | + |
| Pd-171 | RuPhos Pd(crotyl)Cl | + | + |
| Pd-172 | SPhos Pd(crotyl)Cl | + | + |
| Pd-173 | [BrettPhos Pd(allyl)]OTf | + | + |
| Product number | Description | C-C plate | C-N plate |
|---|---|---|---|
| Pd-174 | [tBuXPhos Pd(allyl)]OTf | + | + |
| Pd-175 | [tBuBrettPhos Pd(allyl)]OTf | + | |
| Pd-177 | XantPhos Pd(allyl)Cl | + | + |
| Pd-178 | PCy3 Pd(crotyl)Cl | + | |
| Pd-181 | P(o-tolyl)3 Pd(crotyl)Cl | + | |
| Pd-188 | CyJohnPhos Pd(crotyl)Cl | + | |
| Pd-209 | tBuXPhos Pd G6 | + | |
| Pd-210 | tBuBrettPhos Pd G6 | + | |
| Pd-215 | [RockPhos Pd(allyl)]OTf | + | |
| Pd-216 | [Me3OMettBuXPhos Pd(allyl)]OTf | + | |
| Pd-217 | CPhos Pd(crotyl) Cl | + | |
| Pd-218 | [EPhos Pd(allyl)]OTf | + | |
| Pd-219 | [GPhos Pd(allyl)]OTf | + | |
| Pd-220 | [AlPhos Pd(allyl)OTf | + | |
| Pd-221 | [MorDalPhos Pd(crotyl)OTf | + | |
| BPC-307 | P(Ad)2(nBu) Pd G3 | + | + |
| Ni-132 | Ni(PPh3)2(1-napthyl)Cl | + |
1. Tu, N.P.; Wang, T. RSC Med. Chem. 2026. DOI: 10.1039/D5MD00827A