JM pharma webinars

Access our free webinars below, offering valuable insight for research chemists and process development scientists in the pharmaceutical and fine chemical industries.

All access webinars

Date: April 2021

Length: 1 hour

Poor bioavailability and low efficacy are amongst the most common reasons for drug failure. To address this, various particle engineering techniques have received attention for their ability to improve the solubility and bioavailability of drug compounds. Nanoform’s proprietary CESS® technology is one such technique. Johnson Matthey recently collaborated with Nanoform to evaluate CESS compared with other current approaches, including spray-dried amorphous dispersion, hot-melt extrusion, salt, cocrystal, milled and micron-sized active pharmaceutical ingredients.

Senior Scientist, Claire Wombwell, joined Nanoform’s Chief Technology Officer, Niklas Sandler, to discuss the science behind CESS technology and how it can be leveraged to produce nanoparticles that improve the solubility and bioavailability of drug substances.

This webinar was hosted by The Namomed Zone. You'll need to register your details to gain access to the recorded webinar and slides:

Watch now

Date: August 2020

Length: 1 hour and 15 mins

Crystallisation design is a critical step in the development of many APIs. Optimisation of this process so that it is both scalable and robust can be a time-consuming, labour-intensive process not guaranteed to obtain desirable results. As crystallisation is governed by kinetics as well as thermodynamics, alterations in heat and mass transfer during process scale-up can lead to the appearance of previously unseen and undesirable phenomena on scale. The formation of transient polymorphs and oil-to-crystal transformations which are often short-lived so as to be difficult to observe at lab scale, can become process-limiting on multi kilogram scale. The advent of high-resolution process analytical technology means that such phenomena can be observed at reduced scale. In this presentation, we describe a rational design for the crystallisation of a metastable cocrystal using both modelling and a range of in-situ measurements to minimise experimental burden. A Dynochem® model is developed which describes the crystallisation process and is used to control litre-scale processes from milligram-scale solubility measurements. In process measurements of solution concentration, particle size, particle morphology and crystal form are then used to inform and validate the model. For this, the BlazeMetrics 900 probe is used to identify process changes and guide circumvention of unwanted phenomena. The crystallisation of the metastable cocrystal is successfully scaled-up to validate the model and an accurate prediction of the particle size distribution by the model is realised.

This webinar was hosted by Scientific Update and presented by JM's Dr Joe Harris.

Watch now

Date: June 2020

Length: 56 mins

Choosing the ideal solid form is a crucial point in the life cycle of a molecule. Therefore, it is always best to conduct a thorough search to identify as many forms (polymorphs, salts and cocrystals) as possible to allow you to select the one with the preferred physical/chemical properties and for IP. However, limited material can make this challenging. A well-designed screen, including multiple crystallisation techniques with a diverse set of solvents, can be carried out with little material prioritising analytical techniques to identify solid forms of interest. Furthermore, as a solid form progresses through development, unexpected issues can arise. New forms, oiling out, change in impurity profiles caused by changes in scale, can result in the scrapping of batches, extra production steps or the reset of a molecule potentially costing millions. To minimise risk, crystallisation development driven by Quality by Design (QBD) should be undertaken as soon as possible. Using PAT tools, modelling, design of experiment studies coupled with expert understanding of the solid form and solubility landscape, a scalable, robust process that will give the desired outcome can be built and developed at an early stage of development.

This webinar was presented by Dr Thomas Kendall from Johnson Matthey.

Watch now

 DOWNLOAD q&a 

Date: May 2020

Length: 46 mins

Catalysis has been, for a long time, an established tool in the fine chemicals industry. Yet, application scope, catalysts performance, process understanding as well as our expectations are continually evolving. It is worth examining once again the answers to some basic questions: Why catalysis? Why new catalysts? Which new catalysts? Here, we briefly overviewed the rationale for sustainability, economics, technical complementarity of the homogeneous, heterogeneous and biocatalytic technologies offered by Johnson Matthey.

This webinar was presented by Dr Antonio Zanotti-Gerosa and Dr Danny Mortimer from Johnson Matthey.

WatCH NOW

Date: Jan 2020

Length: 48 mins

Homogeneous ester hydrogenation has evolved into an efficient and cost-effective transformation and provides greener access to primary alcohols, important targets in pharmaceutical and flavour and fragrances chemistry. This webinar provides a deeper understanding of the application of the technology.

This webinar is presented by Dr Antonio Zanotti-Gerosa from Johnson Matthey.

Watch NOW

Sign up

Be the first to hear about similar webinars

Fine chemicals catalysts